A naturally occurring polyunsaturated fatty acid derived from safflower oil that supports healthy body composition and lipid metabolism.
What it is
Conjugated linoleic acid (CLA) refers to a family of positional and geometric isomers of linoleic acid. In dietary supplements, commercial CLA is produced via the controlled isomerisation of linoleic acid derived from safflower seed oil (Carthamus tinctorius). The primary bioactive isomers supplied in equal proportions are cis-9, trans-11 and trans-10, cis-12 CLA. It is formulated in oil softgels or lipid powder forms to maintain stability and bioavailability.
Also known as: CLA from Safflower Oil, Safflower CLA
What it does
- Supports healthy body composition by assisting in fat mass management during energy-restricted diets.
- Helps modulate lipid metabolic pathways and mitochondrial fatty acid beta-oxidation.
- Provides fatty acid substrate support involved in cellular energy regulation.
Amplified by probiotics
Intestinal probiotics possessing active bile-salt hydrolase (BSH) enzymes uncouple conjugated bile acids in the small intestine, modulating the micellar solubilisation required for fatty acid emulsification. This enzymatic modification regulates the uptake of lipophilic molecules like CLA across the apical membrane of enterocytes. Simultaneously, probiotic colonization generates short-chain fatty acids (SCFAs) that reinforce intestinal barrier function and reduce mucosal inflammation. Maintaining gut tight junction integrity prevents lipid peroxide leakage and supports mucosal transport processes, ensuring that dietary CLA is effectively packaged into chylomicrons for systemic distribution without inducing localized intestinal irritation.
Typical dose
3–6 g/day
The evidence
Evidence: moderateMeta-analyses of human randomized controlled trials indicate that daily CLA supplementation produces modest reductions in body fat mass over 12 to 24 weeks (Whigham 2007, Am J Clin Nutr). Long-term clinical studies demonstrate small but statistically significant decreases in fat mass in overweight adults (Blankson 2000, J Nutr).
Safety & who should check first
Generally well tolerated, with mild gastrointestinal discomfort reported at higher doses. Use with caution in diabetes due to potential effects on insulin sensitivity; consult a physician during pregnancy.